Stem cell donation, known as peripheral blood stem cell is a non surgical procedure. Roughly five days before the recipients transplant, the donor will receive daily injections of a drug called neupogen. Neupogen increases blood forming cells in your blood stream. On the day of donation, your blood will be removed from one arm and passed through a machine called apheresis. The apheresis machine separates the formed blood cells. The residual blood is then returned back to the donor in the opposite arm. After a peripheral stem cell donation, the donor can expect to return to normal activity in 1-2 days.

Bone marrow donation is a surgical procedure. The donor will be given anesthesia. While under anesthesia, the doctor will withdraw the liquid marrow from the back of the pelvic bone. Once awakened it is typical to feel soreness in your lower back. Donors who give via bone marrow collection can expect to return to normal activity within 2-7 days.